ABOLISHED KETAMINE EFFECTS ON THE SPONTANEOUS EXCITATORY POSTSYNAPTIC CURRENT OF MEDIAL PREFRONTAL CORTEX NEURONS IN GLUN2D KNOCKOUT MICE

Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice

Abstract Ketamine, a non-competitive antagonist of the N-methyl-d-aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect.It exerts psychomimetic effects, yet demands a further investigation of its mechanism.Previous research showed that ketamine did no longer promote hyperlocomotion in GluN2D knockout (KO) mice, which is a sub

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Microsponges: a breakthrough tool in pharmaceutical research

Abstract Background A microsponge delivery system (MDS) is an innovative and unique way of delivering drugs in a structured manner.Using microsponge drug delivery, regulated drug delivery may now be achieved quickly and easily.Main body MDS comprises porous microspheres ranging in size from 5 to 300 microns, with a large porous structure and a very

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Feasibility of ultrasound-guided posterior approach for interscalene catheter placement during arthroscopic shoulder surgery

BackgroundContinuous interscalene block has been known to improve postoperative analgesia after arthroscopic shoulder surgery.This was a prospective study investigating the ultrasound-guided posterior approach for placement of an interscalene catheter, clinical efficacy and complications after placement of the catheter.MethodsForty-two selle chroma

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